Retrospective analysis of sex-disaggregated immune responses to ALVAC-HIV and bivalent subtype C gp120/MF59 HIV vaccines
We identified sex-based differences in immune responses to an HIV vaccine regimen, but they varied by immunologic assay. While vaccine recipients AFAB demonstrated higher ADCC responses, AMAB exhibited higher CD4+ T cell response rates. Future analyses should investigate whether vaccine factors such as platform, dosing and adjuvants contribute to sex-based differences in immunogenicity of experimental HIV vaccines.
Authors
- Kelly E. Seaton (ORCID: https://orcid.org/0000-0002-2009-3270)
- David C. Montefiori (ORCID: https://orcid.org/0000-0003-0856-6319)
- Mookho Malahleha (ORCID: https://orcid.org/0000-0003-1879-8471)
- Zoe Moodie (ORCID: https://orcid.org/0000-0001-8701-2001)
- Srilatha Edupuganti (ORCID: https://orcid.org/0000-0001-6566-9969)
- Brodie Daniels (ORCID: https://orcid.org/0000-0002-9175-2130)
- Craig Innes (ORCID: https://orcid.org/0000-0002-6872-5687)
- Nonhlanhla N. Mkhize (ORCID: https://orcid.org/0000-0003-3037-1243)
- Georgia D. Tomaras (ORCID: https://orcid.org/0000-0001-8076-1931)
- Marguerite Koutsoukos (ORCID: https://orcid.org/0000-0002-4174-8424)
- Alison C. Roxby (ORCID: https://orcid.org/0000-0001-9449-8062)
- Linda‐Gail Bekker (ORCID: https://orcid.org/0000-0002-0755-4386)
- Cassie Grimsley Ackerley
- Guido Ferrari (ORCID: https://orcid.org/0000-0001-7747-3349)
- Fatima Laher (ORCID: https://orcid.org/0000-0001-5231-9951)
- Nicole L. Yates
- Chenchen Yu
- Jack Heptinstall (ORCID: https://orcid.org/0000-0002-3401-5935)
- Kathryn Therese Mngadi (ORCID: https://orcid.org/0000-0002-7847-3671)
- Briana D. Furch (ORCID: https://orcid.org/0000-0003-3018-1642)
- M. Juliana McElrath (ORCID: https://orcid.org/0000-0003-2276-7117)
- Lynn Morris (ORCID: https://orcid.org/0000-0002-1836-8415)
- Mary Allen
- Stephen C. DeRosa
Institutions
- National Health Laboratory Service (ZA)
- South African Medical Research Council (ZA)
- National Institutes of Health (US)
- Desmond Tutu HIV Foundation (ZA)
- Emory University (US)
- University of Cape Town (ZA)
- Fred Hutch Cancer Center (US)
- Aurum Institute (ZA)
- Duke Medical Center (US)
- National Institute of Allergy and Infectious Diseases (US)
- GlaxoSmithKline (Switzerland) (CH)
- Perinatal HIV Research Unit (ZA)
- Setshaba Research Centre (ZA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1557009
- Citations
- 2
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.07