Plasma neurofilament light chain mediates the effect of subsyndromal symptomatic depression on cognitive decline in older adults
Plasma NfL, which is related to neuroaxonal damage, may partially mediate the association between SSD and accelerated cognitive decline in non-demented older adults. These findings suggest that dynamic changes in plasma NfL levels may reflect early neurobiological alterations associated with SSD and could help identify individuals at increased risk of cognitive deterioration over a 2-year period.
Authors
- Gaoqiankun Huang (ORCID: https://orcid.org/0000-0001-9045-4302)
- Min Gyu Kong (ORCID: https://orcid.org/0000-0003-1336-5319)
- Kok Pin Ng (ORCID: https://orcid.org/0000-0003-3787-8944)
- Chunhua Zhang (ORCID: https://orcid.org/0000-0003-4469-8634)
- Bingyu Li (ORCID: https://orcid.org/0009-0000-9630-8787)
- Xijin Wang
- Maowen Ba (ORCID: https://orcid.org/0000-0003-0621-5558)
Institutions
- Qingdao University (CN)
- Tongji University (CN)
- Yuhuangding Hospital (CN)
- Duke-NUS Medical School (SG)
- Shanghai East Hospital (CN)
- National Neuroscience Institute (SG)
- Yantaishan Hospital (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-05-14
- DOI
- https://doi.org/10.3389/fnagi.2025.1547394
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Alzheimer's Disease Neuroimaging Initiative
- National Institutes of Health