Metabolic and immune consequences of antibiotic related microbiome alterations during first-line tuberculosis treatment in Bamako, Mali
We observed alterations in the gut microbiota composition and function during treatment and at Month-15. Numerous changes in bacterial taxa abundances and inflammation-linked metabolites did not reverse at Month-15. This study suggests potential influences of anti-TB drugs and the gut microbiome on the disease outcome, response to treatment, and resistance to future TB infections.
Authors
- Mamoudou Maïga (ORCID: https://orcid.org/0000-0001-7871-3973)
- Lifang Hou (ORCID: https://orcid.org/0000-0003-4877-0031)
- A. Koné (ORCID: https://orcid.org/0000-0002-6736-3653)
- Bassirou Diarra (ORCID: https://orcid.org/0000-0002-1795-9379)
- Dramane Diallo (ORCID: https://orcid.org/0000-0001-9761-3652)
- Bocar Baya (ORCID: https://orcid.org/0000-0002-0978-7503)
- Jane Louise Holl (ORCID: https://orcid.org/0000-0002-2934-1672)
- Anou M. Somboro (ORCID: https://orcid.org/0000-0002-1085-7740)
- Grant Theron (ORCID: https://orcid.org/0000-0002-9216-2415)
- Shan Sun (ORCID: https://orcid.org/0000-0003-0349-2664)
- Mohamed Nantoumé
- Isaac Koloma
- Mahamadou Diakité (ORCID: https://orcid.org/0000-0002-4268-8857)
- Almoustapha Issiaka Maiga
- Anthony A. Fodor (ORCID: https://orcid.org/0000-0002-9305-4264)
- Moussa Seydi (ORCID: https://orcid.org/0000-0002-0977-1085)
Institutions
- University of North Carolina at Charlotte (US)
- South African Medical Research Council (ZA)
- Northwestern University (US)
- University of Chicago (US)
- University of Bamako (ML)
- Université des Sciences, des Techniques et des Technologies de Bamako (ML)
- Centre Hospitalier National Universitaire de Fann (SN)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1561459
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Northwestern University
- National Institutes of Health