Molecular characterization of carbapenem resistance mechanisms and phenotypic correlations in clinical Klebsiella pneumoniae isolates from Ningbo, China
In the region, CRKP showed high sensitivity to tigecycline, polymyxin B, ceftazidime-avibactam, fosfomycin, amikacin, and chloramphenicol. The main carbapenemase genes identified were <i>KPC-2</i> and <i>NDM-5</i>. The inhibitory effects of ceftazidime-avibactam, aztreonam, and amikacin varied for CRKP carrying different enzyme types. ST11 strains were predominant in the region. There was a significant difference in the resistance genes carried by ST11 strains compared to non-ST11 strains. Clonal dissemination was observed both within the same healthcare institution and between different institutions.
Authors
- Chenyao Lin
- Qingcao Li (ORCID: https://orcid.org/0000-0002-8769-8370)
- Xuedan Qiu
- Qiaoping Wu (ORCID: https://orcid.org/0000-0002-8796-2952)
- Jianqiang Xu (ORCID: https://orcid.org/0000-0002-1289-5943)
- Min Jiang (ORCID: https://orcid.org/0000-0002-0839-7992)
- Weiying Li (ORCID: https://orcid.org/0000-0002-5767-6779)
Institutions
- Ningbo College of Health Sciences (CN)
- Ningbo University Affiliated Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.3389/fmicb.2025.1546805
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical and Health Research Project of Zhejiang Province