Capsaicin induces ferroptosis via suppression of SLC7A11 activity and upregulation of ACSL4 mediated by AMPK in tongue squamous cell carcinoma
Our study demonstrates that CAP activate the AMPK signaling, inhibits the activity of SLC7A11 and increases ACSL4 expression, thereby inducing ferroptosis in TSCC. These findings, supported by <i>in vivo</i> data, highlight CAP's role in triggering ferroptosis as an anti-TSCC mechanism.
Authors
- Mengyang Wang (ORCID: https://orcid.org/0000-0003-2406-9996)
- Qiushi Cao
- Li Zhuang (ORCID: https://orcid.org/0000-0001-9056-7681)
- Yaqin Sun (ORCID: https://orcid.org/0000-0003-0700-762X)
- Yiling Huang
- Long Ding
- Qiwei Zhao
- Xiaohong Guo (ORCID: https://orcid.org/0000-0001-9733-5592)
- Yu Wang (ORCID: https://orcid.org/0000-0003-1286-2401)
Institutions
- Hubei University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.3389/fonc.2025.1532555
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanxi Medical University