CD44 knockdown alters miRNA expression and their target genes in colon cancer
Our findings suggest a regulatory relationship between CD44, Let-7 miRNAs, and STAT3 in HT-29 tumors. Additionally, we propose the potential involvement of both isoforms of miR-203a (canonical and its +1 5'-isoform) in this regulatory network and suggest a role for miR-101-3p and miR-125a-5p in metastasis regulation through CD44 kd.
Authors
- D. V. Maltseva (ORCID: https://orcid.org/0000-0002-4960-5348)
- Anton Zhiyanov (ORCID: https://orcid.org/0000-0002-2866-9692)
- Tobias Lange (ORCID: https://orcid.org/0000-0001-6632-337X)
- Alexander Tonevitsky (ORCID: https://orcid.org/0000-0002-7079-7145)
Institutions
- National Research University Higher School of Economics (RU)
- Institute of Bioorganic Chemistry (RU)
- University of Lübeck (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1552665
- Citations
- 2
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Thomas Jefferson University
- National Research University Higher School of Economics