RNA-binding protein gene NOP58 exhibits crucial prognostic and therapeutic value in Ewing sarcoma

Collectively, downregulation of NOP58 could inhibit the proliferation and migration of EwS cells in vitro and reduce murine xenograft tumor growth in vivo. These findings identified NOP58 as a promising regulator of EwS tumorigenesis, suggesting it may serve as a potential therapeutic target for EwS treatment.

Authors

Rui Shao (ORCID: https://orcid.org/0000-0003-0090-9604)
Lu Yang (ORCID: https://orcid.org/0000-0002-3955-150X)
Tiantong Xu (ORCID: https://orcid.org/0000-0003-3877-4098)
Lilong Zhang (ORCID: https://orcid.org/0000-0002-3360-1158)
Yang Geng (ORCID: https://orcid.org/0009-0000-4651-4101)

Institutions

Tianjin First Center Hospital (CN)
Tianjin Medical University Cancer Institute and Hospital (CN)
Tianjin Medical University (CN)

Publication Details

Journal: Hereditas
Published: 2025-05-14
DOI: https://doi.org/10.1186/s41065-025-00440-5
Citations: 2
Primary Topic: RNA Research and Splicing
Type: article
Field-Weighted Citation Impact: 1.61

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article

RNA-binding protein gene NOP58 exhibits crucial prognostic and therapeutic value in Ewing sarcoma

Rui Shao, Lu Yang, Tiantong Xu, Lilong Zhang et al.

May 14, 2025

2 citations

Hereditas

RNA Research and Splicing

1.61

article

RNA-binding protein gene NOP58 exhibits crucial prognostic and therapeutic value in Ewing sarcoma

Rui Shao, Lu Yang, Tiantong Xu, Lilong Zhang, Yang Geng

May 14, 2025article en

2 citations

Abstract

Collectively, downregulation of NOP58 could inhibit the proliferation and migration of EwS cells in vitro and reduce murine xenograft tumor growth in vivo. These findings identified NOP58 as a promising regulator of EwS tumorigenesis, suggesting it may serve as a potential therapeutic target for EwS treatment.

HereditasVol. 162(1)

Tianjin First Center Hospital (CN), Tianjin Medical University Cancer Institute and Hospital (CN), Tianjin Medical University (CN)

No poverty

Openalex Percentile: Top 17%

RNA Research and Splicing

1.61

DOI Open Access PDF OpenAlex

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