EGFR polymorphisms drive lung cancer risk and survival disparities: a genotype-expression-outcome cohort study
EGFR rs2293347 (pan-subtype) and rs884225 (LUAD-specific) polymorphisms increase LC risk through elevated protein expression, with rs2293347-TT conferring worse survival. These genotype-protein correlations highlight their dual role as susceptibility markers and prognostic predictors in precision oncology.
Authors
- Chao Zuo (ORCID: https://orcid.org/0000-0002-1461-0032)
- Jing Cheng (ORCID: https://orcid.org/0000-0001-8761-8927)
- Dongli Yang (ORCID: https://orcid.org/0000-0001-5026-3149)
- Yi Liu (ORCID: https://orcid.org/0000-0001-8451-6079)
- Ziqiang Wang (ORCID: https://orcid.org/0000-0002-4676-3447)
- Yu Wang (ORCID: https://orcid.org/0000-0002-8645-3435)
- Yongchao Qiao (ORCID: https://orcid.org/0000-0002-2902-9566)
Institutions
- Bengbu Medical College (CN)
- Guilin Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-05-14
- DOI
- https://doi.org/10.3389/fgene.2025.1591539
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangxi Province
- Division of Graduate Education