Milk phospholipid-coated lipid droplets modulate the infant gut microbiota and metabolome influencing weight gain
The presence of large phospholipid-coated lipid droplets in formula milk positively influenced the development of the infants' gut microbiota, their metabolomic profiles, and their body composition to more closely resemble breast-fed infants compared to standard IF. These droplets may further enhance the restriction of pathogenic bacteria seen with standard infant formula and suggest a potential impact on infant metabolic programming that may contribute to physiological development. Video Abstract.
Authors
- Alicia Rodríguez (ORCID: https://orcid.org/0000-0003-0683-7488)
- Elizabeth A Wimborne (ORCID: https://orcid.org/0000-0001-8471-4489)
- Franklin L. Nóbrega (ORCID: https://orcid.org/0000-0002-8238-1083)
- Yi Wu (ORCID: https://orcid.org/0000-0001-5965-0399)
- Jonathan R. Swann (ORCID: https://orcid.org/0000-0002-6485-4529)
- Nana Bartke (ORCID: https://orcid.org/0000-0002-8805-5238)
- Guus Roeselers (ORCID: https://orcid.org/0000-0002-4725-6105)
- Jan Knol (ORCID: https://orcid.org/0000-0002-2103-5961)
- Simone Zuffa (ORCID: https://orcid.org/0000-0001-7237-3402)
- Anita C. S. Hokken‐Koelega
- Christophe Lay
Institutions
- University of California San Diego (US)
- Danone (Netherlands) (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Clinical Nutrition Research Centre (SG)
- University of Southampton (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Microbiome
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s40168-025-02106-w
- Citations
- 4
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 4.48
Funders
- Danone
- National Institute for Health and Care Research
- National Institute for Health Research Southampton Biomedical Research Centre
- Medical Research Council
- Biotechnology and Biological Sciences Research Council