Inhibition of ferroptosis by <i>N</i> -oxide-based fluorescent probes <i>via</i> selective oxidation of ferrous ions
Ferroptosis, a form of iron-dependent programmed cell death, is linked to various diseases and physiological processes. Despite the availability of various types of ferroptosis inducers, its inhibitors are limited to iron chelators or radical scavengers. This study demonstrates that Fe(ii)-selective fluorescent probes developed in our lab could serve as ferroptosis inhibitors <i>via</i> selective oxidation of Fe(ii), which is required for lipid peroxidation. This finding opens the door to a new class of ferroptosis inhibitors with potential therapeutic applications.
Authors
- Hideko Nagasawa (ORCID: https://orcid.org/0000-0002-7662-0762)
- Kanta Kawai
- Shunsuke Nozawa (ORCID: https://orcid.org/0000-0003-4977-6849)
- Tasuku Hirayama (ORCID: https://orcid.org/0000-0003-4541-7849)
- Rie Haruki (ORCID: https://orcid.org/0009-0009-7367-1458)
Institutions
- High Energy Accelerator Research Organization (JP)
- Gifu Pharmaceutical University (JP)
- Japan Science and Technology Agency (JP)
Publication Details
- Journal
- Chemical Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4sc07972h
- Citations
- 5
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Takeda Science Foundation
- Takeda Foundation
- Japan Society for the Promotion of Science
- Precursory Research for Embryonic Science and Technology