Esculetin inhibits liver cancer by targeting glucose-6-phosphate isomerase mediated glycolysis
This study demonstrated the inhibitory effects of esculetin against liver cancer both in vitro and in vivo, demonstrating inhibition of glycolysis in liver cancer cells. In addition, the key glycolysis enzyme GPI was identified as a direct target of esculetin.
Authors
- Xin Tu (ORCID: https://orcid.org/0000-0001-6470-980X)
- Xueyun Duan (ORCID: https://orcid.org/0000-0002-0324-1868)
- Zongchao Hong (ORCID: https://orcid.org/0000-0003-1381-4479)
- Jingbo Wang (ORCID: https://orcid.org/0000-0002-4961-0921)
- Burong Hu (ORCID: https://orcid.org/0000-0003-0156-9154)
- Jin Kuk Yang (ORCID: https://orcid.org/0000-0003-3824-9963)
- Wanjin Sun
Institutions
- Minzu University of China (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
- Anhui Special Equipment Inspection Institute (CN)
- The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture (CN)
- Minda Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1016/j.biopha.2025.118118
- Citations
- 5
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.03