Clinicopathologic and Molecular Characterization of SMARCB1-Deficient Sinonasal Carcinomas – A Systematic Study from a Single Institution Cohort
SMARCB1-deficient carcinomas account for 4.7% of sinonasal carcinomas in this single-institution cohort, while SMARCA4-deficient tumors are even rarer, with none identified. SMARCB1-deficient sinonasal carcinomas exhibit a broad spectrum of morphologic and immunohistochemical features. These carcinomas show complex genetic alterations, with homozygous SMARCB1 deletions present in the majority of cases.
Authors
- Paul M. Harari (ORCID: https://orcid.org/0000-0002-6207-5505)
- Wei Huang (ORCID: https://orcid.org/0000-0003-0813-4188)
- Andrey Prilutskiy (ORCID: https://orcid.org/0000-0002-4520-8871)
- Rong Hu (ORCID: https://orcid.org/0000-0002-1502-9848)
- Leah Frater-Rubsam (ORCID: https://orcid.org/0000-0003-2852-8432)
- Randall J. Kimple (ORCID: https://orcid.org/0000-0001-8336-8000)
- Qinyuan Li (ORCID: https://orcid.org/0000-0002-4052-5747)
- Tarek Abi-Saab
- Yajing Peng
- Vanessa L. Horner
- Ricardo V. Lloyd
Institutions
- University of Wisconsin System (US)
- University of Wisconsin–Madison (US)
Publication Details
- Journal
- Head and Neck Pathology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1007/s12105-025-01788-w
- Citations
- 1
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81