Progress in Investigating Low-Intensity Focused Ultrasound for the Treatment of Neurological Diseases

无创神经调节技术是治疗神经系统疾病的重要手段，多个研究证明低强度聚集超声(Low-intensity focused ultrasound, LIFU)可应用于多种神经系统疾病，如癫痫、阿尔茨海默病、帕金森病等，并显现出了积极的疗效。LIFU可以穿透颅骨，聚集于大脑深部核团，具有无创、高精确性、高穿透深度等优点。本文通过回顾LIFU的技术进展、作用机制以及在神经系统疾病治疗中的应用，总结了LIFU作为一种新型的无创神经调节技术，在神经系统疾病治疗方面的应用前景。研究表明，LIFU通过靶向调控神经元活性及神经可塑性，可能具有改善神经功能障碍的临床转化价值。本综述为LIFU技术的科学化应用与临床转化研究提供了理论框架与方法学参考。Noninvasive neuromodulation techniques are important for the treatment of neurological diseases. Several studies have demonstrated that low-intensity focused ultrasound (LIFU) can be utilized in various neurological diseases, such as epilepsy, Alzheimer’s disease, and Parkinson’s disease, with promising therapeutic effects. LIFU has the ability to penetrate the skull and target deep brain structures, offering advantages such as non-invasiveness, high precision, and significant depth of penetration. This review discusses the technical advancements, mechanisms of action, and clinical applications of LIFU in treating neurological diseases. It summarizes the potential of LIFU as a novel non-invasive neuromodulation technology for the treatment of neurological diseases. The study suggests that LIFU may have clinical translational value in improving neurological dysfunction by targeting and modulating neuronal activity and neuroplasticity. This review provides a theoretical framework and methodological reference for the scientific application and clinical translational research of LIFU technology.