Rhodium-Catalyzed Aromatic C–H Allylation with α,β-Unsaturated Imines
Reaction of 2-arylpyridines with α,β-unsaturated imines in the presence of 2.5 mol % of [Cp*RhCl<sub>2</sub>]<sub>2</sub> and 10 mol % of AgSbF<sub>6</sub> in acetone affords allylated 2-arylpyridines with an enamine unit located in the allyl segment. This method features <i>ortho</i>-monoallylation selectivity and <i>Z</i>-selectivity of the C-C double bonds, is applicable to a wide range of substrates, and is compatible with air and functional groups such as halides, CF<sub>3</sub>, COOMe, OH, MeO, and ketal groups.
Authors
- Weitao Hu
- Zhong‐Xia Wang (ORCID: https://orcid.org/0000-0001-8126-8778)
Institutions
- University of Science and Technology of China (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1021/acs.joc.5c00484
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China