Unveiling the Hydrogen Isotope Separation Potential of <b>MIL-101 (Cr)</b> under Elevated Temperatures

The separation of hydrogen isotopes under moderate conditions remains a significant challenge, primarily due to their nearly identical physicochemical properties. Among emerging approaches, the chemical affinity quantum sieving (CAQS) effect in porous materials has shown promise for achieving selective adsorption at elevated temperatures. Herein, we evaluate the isotope separation performance of <b>MIL-101 (Cr)</b>, a hydrothermally stable metal-organic framework featuring supertetrahedral cages and open metal sites. The synergistic interaction between these structural motifs imparts a high adsorption enthalpy, promoting strong isotope-framework interactions. In combination with its large pore size and high porosity, which enhance molecular exchange, <b>MIL-101 (Cr)</b> exhibits effective hydrogen isotope separation, as confirmed by dynamic breakthrough experiments conducted up to 100 K.