Salidroside can protect against ferroptosis in cardiomyocytes and may be related to the regulation of GGT1
These findings establish GGT1 as a pivotal therapeutic target for SAL's cardioprotection, providing a mechanistic basis for its clinical application in ferroptosis-associated cardiovascular diseases.
Authors
- Sha Wan
- Qin Zhao (ORCID: https://orcid.org/0000-0002-3519-9190)
- Jinghua Zhao
- Sijia Wang (ORCID: https://orcid.org/0000-0002-3790-8704)
- Tao Wang (ORCID: https://orcid.org/0000-0001-7087-4596)
- Tianhang Feng
- Jing Shi (ORCID: https://orcid.org/0000-0002-5327-8079)
- Yutong Yao (ORCID: https://orcid.org/0000-0002-7058-5337)
- Fan Chen (ORCID: https://orcid.org/0000-0002-0530-9248)
- Chunyou Lai (ORCID: https://orcid.org/0009-0005-2290-4785)
Institutions
- University of Electronic Science and Technology of China (CN)
- Chengdu Medical College (CN)
- West China Medical Center of Sichuan University (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.3389/fphar.2025.1580506
- Citations
- 2
- Primary Topic
- Medicinal Plants and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.61