Characterizing differences in the muscle transcriptome between cattle with alternative LCORL-NCAPG haplotypes
The differences in the muscle transcriptome between QQ and qq animals imply that muscle hypertrophy may be metabolically favored over accumulation of fat in animals with the QQ haplotype. Our findings also suggest this haplotype could be linked to a difference in LCORL expression that potentially influences the downstream transcriptional effects observed, though further research will be needed to confirm the molecular mechanisms underlying the associated changes in phenotype.
Authors
- Dan W. Shike
- Jonathan E. Beever (ORCID: https://orcid.org/0000-0001-6156-0632)
- A. C. Dilger (ORCID: https://orcid.org/0000-0003-0233-8278)
- Christopher J Cassady
- Joshua C McCann (ORCID: https://orcid.org/0000-0002-1305-8098)
- Fernanda Martins Rodrigues (ORCID: https://orcid.org/0000-0002-2140-0690)
- Leif E. Majeres (ORCID: https://orcid.org/0009-0009-6887-770X)
Institutions
- University of Illinois Urbana-Champaign (US)
- Iowa State University (US)
- University of Tennessee at Knoxville (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s12864-025-11665-z
- Citations
- 4
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- U.S. Department of Agriculture
- National Institute of Food and Agriculture