Novel Aortic Dissection Model Links Endothelial Dysfunction and Immune Infiltration
We show that interactions involving endothelial cells and macrophages/monocytes in the intima, where the extracellular matrix (ECM) microenvironment contains reduced TGFβ signaling, contribute to the initiation of AD. Our novel AD mouse model provides a unique opportunity to identify target molecules involved in the intimomedial tears that can be utilized for the development of therapeutic strategies.
Authors
- Lynn Y. Sakai (ORCID: https://orcid.org/0000-0003-0054-1539)
- Ryutaro Ishii (ORCID: https://orcid.org/0000-0002-7919-6354)
- Sachiko Kanki (ORCID: https://orcid.org/0000-0003-4530-6006)
- Kazuya Murata (ORCID: https://orcid.org/0000-0002-3328-069X)
- Erna Raja (ORCID: https://orcid.org/0000-0001-7490-7965)
- Patrick Sips (ORCID: https://orcid.org/0000-0001-9241-5980)
- Julie De Backer (ORCID: https://orcid.org/0000-0001-8878-1507)
- Seiya Mizuno (ORCID: https://orcid.org/0000-0002-6740-5817)
- Violette Deleeuw (ORCID: https://orcid.org/0000-0001-8733-1854)
- Laura Muiño Mosquera (ORCID: https://orcid.org/0000-0002-3094-7807)
- Hiromi Yanagisawa (ORCID: https://orcid.org/0000-0002-7576-9186)
- Maria Thea Rane Dela Cruz Clarin
- Tomoyuki Nakamura (ORCID: https://orcid.org/0000-0002-8017-9818)
- Kenichi Kimura (ORCID: https://orcid.org/0000-0002-0363-8865)
- Keiichi Asano
- Mariko Takeda
- Eri Motoyama
- Md Al Amin Sheikh
Institutions
- HOGENT University of Applied Sciences and Arts (BE)
- Kansai Medical University (JP)
- University of Tsukuba (JP)
- Oregon Health & Science University (US)
- National Institute for Environmental Studies (JP)
- National Institute for Materials Science (JP)
- Ghent University Hospital (BE)
- Ghent University (BE)
- Osaka University of Pharmaceutical Sciences (JP)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1161/circresaha.125.326230
- Citations
- 11
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 16.70
Funders
- University of Tsukuba