Concentration Estimation of Apixaban and Rivaroxaban in Plasma From Patients Through Heparin‐Calibrated Anti‐Xa Assay Generated Different Results by Using 3 Reagent/Calibrators/Instrument Systems

Estimation of APIXA or RIVA concentration through HC-Anti Xa is possible, but values obtained are different for each reagent/calibrator/instrument system. Knowledge of the HC-Anti Xa values corresponding to anticoagulant concentrations at clinical decision points in the system used by each laboratory is mandatory to be able to use them correctly in the clinic.

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Publication Details

Journal
International Journal of Laboratory Hematology
Published
2025-05-14
DOI
https://doi.org/10.1111/ijlh.14497
Primary Topic
Atrial Fibrillation Management and Outcomes
Type
article
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article

Concentration Estimation of Apixaban and Rivaroxaban in Plasma From Patients Through Heparin‐Calibrated Anti‐Xa Assay Generated Different Results by Using 3 Reagent/Calibrators/Instrument Systems

Cristina Duboscq, Marta Martinuzzo, Mirta Arias, Emanuel Sueldo et al.
International Journal of Laboratory Hematology
Atrial Fibrillation Management and Outcomes
article

Concentration Estimation of Apixaban and Rivaroxaban in Plasma From Patients Through Heparin‐Calibrated Anti‐Xa Assay Generated Different Results by Using 3 Reagent/Calibrators/Instrument Systems

Cristina Duboscq, Marta Martinuzzo, Mirta Arias, Emanuel Sueldo, Fernando Chuliber, Luis Barrera, Claudio Martín Rosa, Marina Sol López, José Ceresetto, C. Berger, Verónica Privitera
article en

Abstract

Estimation of APIXA or RIVA concentration through HC-Anti Xa is possible, but values obtained are different for each reagent/calibrator/instrument system. Knowledge of the HC-Anti Xa values corresponding to anticoagulant concentrations at clinical decision points in the system used by each laboratory is mandatory to be able to use them correctly in the clinic.

International Journal of Laboratory HematologyVol. 47(5)
Hospital Italiano de Buenos Aires (AR), Hospital Universitario Austral (AR), Hospital Británico de Buenos Aires (AR), Universidad Hospital Italiano (AR), Hospital César Milstein (AR)
Good health and well-being
Openalex Percentile: Top 81%
Atrial Fibrillation Management and Outcomes
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