Associations between ionomic profile and metabolic abnormalities in a murine model of sodium sulfide induced alopecia areata
Tofacitinib inhibits CD8<sup>+</sup> T cell infiltration in hair follicles affected by sodium sulfide-induced AA by modulating the linoleic acid metabolism-Mg<sup>2+</sup> pathway. Our findings offer new insights and potential avenues for the clinical diagnosis and treatment of AA, suggesting that targeting metabolic and ionic pathways could enhance therapeutic outcomes.
Authors
- Wenxue Sun
- Wei Wang (ORCID: https://orcid.org/0000-0003-2302-6273)
- You Zhai (ORCID: https://orcid.org/0000-0002-7972-1462)
- Zhen Sun (ORCID: https://orcid.org/0000-0001-7228-2586)
- Luning Li (ORCID: https://orcid.org/0000-0002-1591-6279)
- Na Ding (ORCID: https://orcid.org/0000-0003-2109-8265)
Institutions
- Jining First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.3389/fphar.2025.1507348
- Primary Topic
- Hair Growth and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00