Efficacy of mild hypothermia combined with monosialotetrahexosyl ganglioside in the treatment of neonatal hypoxic-ischemic encephalopathy and its effect on serum inflammation, GFAP and NSE levels

Background and purpose Analyze the efficacy of mild hypothermia combined with monosialotetrahexosyl ganglioside in the treatment of neonatal hypoxic ischemic encephalopathy (HIE) and its effect on serum inflammation and serum glial fibrillary acidic protein (GFAP),effect of neuron specific enolase (NSE) levels. 98 children with HIE admitted to our hospital from June 2020 to June 2024 were randomly divided into a control group and an observation group with 49 cases in each group. On the basis of routine oxygen inhalation treatment, the control group was treated with monosialotetrahexosyl ganglioside, and the observation group was treated with mild hypothermia on the basis of the control group. After 14 days of treatment, the treatment efficacy and functional recovery time [muscle tone, sucking ability, primitive reflexes] were compared between the two groups. The levels of serum inflammation-related indicators [high-sensitivity C-reactive protein (hs-CRP), micro-molecule ribonucleic acid-384 (miR-384)] and nerve damage markers [GFAP, NSE, B lymphomas-2 (Bcl-2)] were compared between the two groups before and after treatment. After 14 days of treatment, compared with the control group, the total effective rate of treatment in the observation group was significantly higher (P<0.05). The recovery time of muscle tension, sucking ability, and original reflexes was significantly shorter (P<0.05). After 14 days of treatment, hs-CRP, GFAP, NSE, and Bcl-2 decreased in both groups, and compared with the control group, the levels in the observation group were lower (P<0.05) . The levels of miR-384 increased, and compared with the control group, the levels in the observation group were higher (P<0.05). Mild hypothermia combined with monosialotetrahexosyl ganglioside is effective in treating children with HIE. It can reduce their inflammation level, relieve nerve damage, and be conducive to the recovery of muscle tone and other functions.