Synphilin-1 regulates mechanotransduction in rigidity sensing through interaction with zyxin
These findings provide novel insights into the biophysical functions of synphilin-1, suggesting a potential protective role to the altered extracellular matrix, which may be relevant to neurodegenerative conditions such as Parkinson's disease.
Authors
- Seok Gi Kim (ORCID: https://orcid.org/0000-0002-5914-2471)
- Ji Su Hwang (ORCID: https://orcid.org/0000-0001-9422-1880)
- Gwang Lee (ORCID: https://orcid.org/0000-0002-1299-9478)
- Jung‐Soon Mo (ORCID: https://orcid.org/0000-0001-9462-329X)
- Sungsu Park (ORCID: https://orcid.org/0000-0003-3062-1302)
- Ye Eun Sim
- Ju Yeon Lee (ORCID: https://orcid.org/0000-0003-0855-6516)
- Jinyan Li (ORCID: https://orcid.org/0000-0002-0499-5346)
- Myeong Ok Kim (ORCID: https://orcid.org/0000-0003-4317-1072)
- Mohamed F. Y. Hassan (ORCID: https://orcid.org/0000-0002-6027-3989)
Institutions
- Gyeongsang National University (KR)
- Korea Basic Science Institute (KR)
- Ajou University (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s12951-025-03429-4
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Ajou University
- Korea Basic Science Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea