THE MAIN DIRECTIONS AND PROBLEMS IN THE DEVELOPMENT OF A VACCINE AGAINST TOXOPLASMA GONDII

Toxoplasma gondii is known to cause congenital infection in humans, animals, and severe illness in immunocompromised individuals. Therefore, the development of vaccines against the parasite is necessary. Despite significant advances in the development of effective vaccines against toxoplasmosis, the search for new vaccination strategies remains challenging. Over the past few years, various experimental approaches have shown that the development of a vaccine against T. gondii is possible. This review summarizes the achievements in the development of T. gondii vaccines and the main obstacles to the creation of a safe, effective and longlasting vaccine. Successes and failures in the development and testing of candidate vaccines are also discussed.