INDICATORS OF THE FUNCTIONS OF THE HEPATOBILIARY SYSTEM IN PATIENTS WITH CHRONIC OPISTHROCHISIS WITH GENETIC PREDISPOSITION TO THE DEVELOPMENT OF ISCHEMIC HEART DISEASE

Tyumen Infection Pathology Research Institute To assess the influence of genetic features that provide a predisposition to the development of coronary heart disease on the reactivity of the hepatobiliary system in opisthorchiasis invasion, a study of biochemical parameters was conducted in subgroups of patients with chronic opisthorchiasis with and without mutations in the corresponding loci. It was found that the presence of a mutation in the rs133304 locus of the CDKN 2A/2B gene increases deviations in GGT activity from the level of healthy individuals caused by opisthorchiasis invasion, apparently aggravating bile secretion disorders, and slows down the normalization of the integral indicator of the state of hepatocytes – bilirubin – after treatment, while contributing to a decrease in cholesterol concentration and an increase in glucose concentration during treatment. The presence of a rare allele in the rs17602729 locus of the AMPD1 gene, on the contrary, has a protective effect on the process of bile secretion in CO (judging by the activity of GGT and ALP), and also smooths out changes in the parameters during therapy. The presence of a mutant allele in the rs133304 locus of the HIF1A gene prevents an increase in the concentration of bilirubin and glucose, accelerates the normalization of GGT activity after therapy, which can be considered a positive effect in CO, but does not affect the increase in ALP activity in the first days after treatment, reflecting the persistence of difficulties in bile secretion. Mutation in the rs3025058 locus of the MMP3 gene has some positive effect on the dynamics of changes in aminotransferases and bilirubin and cholesterol levels during treatment, but contributes to an increase in glucose levels after therapy.