Mucoadhesive Polymer-Based Formulations for Drug Delivery

Over the years, muco-adhesive systems, have been explored in order to obtain a controlled and efficient drug delivery.These systems also provide therapeutic benefits and increased retention time.Muco-adhesive polymers are biopolymers that adhere to the mucosal surface layer for an extended period of time.There are certain muco-adhesive systems that have the tendency to be easily eroded, tasteless and possess low cost.With these properties, they can reduce dosing frequency and also enhance patient safety.Although there are limitations that hinder the performance of muco-adhesive systems such as permeation and enzymatic barriers of the mucosa, these challenges could be overcome by research and development (R and D).The aim of this review was to elaborate on the different aspects of muco-adhesive polymers which include majorly the mechanisms, theories, principles and properties.