Preimplantation Genetic Testing for Aneuploidy in Recurrent Pregnancy Loss: A Fertility Success Story

Recurrent pregnancy loss (RPL) is a challenging condition in the field of assisted reproduction, with various potential causes that may be maternal or fetal in origin. When fetal factors are involved, preimplantation genetic testing for aneuploidy (PGT-A) serves as an effective method to assess embryo genetic integrity, helping identify viable embryos with a higher likelihood of implantation and live birth. This report describes the case of a 30-year-old woman with a history of recurrent miscarriages. After a comprehensive evaluation of possible maternal and paternal factors, and three additional pregnancy losses confirmed to be due to aneuploidy, she underwent in vitro fertilization combined with PGT-A. This resulted in the identification of seven euploid blastocysts. A single embryo transfer led to an ongoing pregnancy, highlighting the clinical utility of PGT-A in the management of RPL.