Prevalence and clinical significance of potential drug-drug interactions of antimicrobials in Intensive Care Unit patients: a retrospective study
High pDDI rates involving antimicrobials were observed in ICU patients, though actual DDIs were infrequent. Notable severe risk pairs warrant vigilant monitoring, especially with a higher occurrence of actual DDIs. Discrepancies in DDI databases emphasize the need for multi-tool validation to optimize medication safety.
Authors
- Shanshan Xu (ORCID: https://orcid.org/0000-0001-6137-2738)
- Zhihui Song
- Jiawei Wang (ORCID: https://orcid.org/0000-0003-2627-4897)
- Jie Bai (ORCID: https://orcid.org/0000-0002-0854-7604)
Institutions
- Beijing Tongren Hospital (CN)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s40360-025-00925-z
- Citations
- 3
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 4.18