Pre-Formulation Studies of Lipid-Based Formulation Approach for a Poorly Water-Soluble Biopharmaceutics Classification System Class II Model Drug: Bosentan

Pre-formulation and formulation studies were carried out successfully, and lipid-based optimum BOS-loaded SNEDDS were obtained. The present study confirms the potential of optimum BOS-loaded SNEDDS, which was found to be stable over the long term, to increase the drug's solubility, <i>in vitro</i> dissolution, and <i>ex vivo</i> permeability. This formulation approach has been promising for further <i>in vivo</i> studies, to improve the oral bioavailability of BOS.