BCR::ABL1 expression in chronic myeloid leukemia cells in low oxygen is regulated by glutamine via CD36-mediated fatty acid uptake
These findings underscore the central role of FA in the regulation of the LSC compartment of CML, highlighting the importance of Gln in facilitating CML cell survival under restrictive metabolic conditions and preparing the cell population for expansion upon the release of these restrictions.
Authors
- Laura Papucci (ORCID: https://orcid.org/0000-0002-8450-7428)
- Daniele Guasti (ORCID: https://orcid.org/0000-0002-2856-6829)
- Silvia Peppicelli (ORCID: https://orcid.org/0000-0001-6459-0458)
- Giuseppe Pieraccini (ORCID: https://orcid.org/0000-0003-3103-3924)
- Persio Dello Sbarba (ORCID: https://orcid.org/0000-0001-6411-569X)
- Caterina Mancini (ORCID: https://orcid.org/0000-0002-5494-8142)
- Alessio Biagioni (ORCID: https://orcid.org/0000-0002-6193-7417)
- Matteo Lulli (ORCID: https://orcid.org/0000-0002-8528-4094)
- Giampaolo Versienti (ORCID: https://orcid.org/0000-0002-9983-9185)
- Giulio Menegazzi
- Elisabetta Rovida (ORCID: https://orcid.org/0000-0002-5949-3239)
Institutions
- University of Florence (IT)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s12935-025-03805-y
- Citations
- 5
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 8.85
Funders
- Associazione Italiana per la Ricerca sul Cancro
- Fondazione Pezcoller