The RNA-binding protein YTHDF3 affects gastric cancer cell migration and response to paclitaxel by regulating EZRIN
YTHDF3 contributes to cell motility and response to paclitaxel in GC cell lines, at least in part through EZR regulation. The YTHDF3-EZR regulatory axis is a novel molecular player in GC, with clinical relevance and potential therapeutic utility.
Authors
- Ricardo Coelho (ORCID: https://orcid.org/0000-0002-9340-3612)
- Diana Pádua (ORCID: https://orcid.org/0000-0002-5780-9842)
- Raquel Almeida (ORCID: https://orcid.org/0000-0002-5622-1633)
- Nelson Leça (ORCID: https://orcid.org/0000-0001-9284-4507)
- Alexandre Coelho (ORCID: https://orcid.org/0000-0001-8715-849X)
- Catarina de Oliveira
- Cármen Jerónimo (ORCID: https://orcid.org/0000-0003-4186-5345)
- Luís Filipe Costa Póvoas (ORCID: https://orcid.org/0000-0002-7599-2142)
- Joana Paredes (ORCID: https://orcid.org/0000-0002-1076-1343)
- Ana Sofia Ribeiro (ORCID: https://orcid.org/0000-0002-9698-9233)
- Patrícia Mesquita (ORCID: https://orcid.org/0000-0002-4766-9831)
- Carlos Conde (ORCID: https://orcid.org/0000-0002-4177-8519)
- Sara Silva (ORCID: https://orcid.org/0000-0001-8268-2137)
- Bruno Pereira (ORCID: https://orcid.org/0000-0003-2460-6720)
- Diana Ferreira (ORCID: https://orcid.org/0000-0002-7737-185X)
Institutions
- Universidade do Porto (PT)
- University of Basel (CH)
- University Hospital of Basel (CH)
- Instituto Português de Oncologia Francisco Gentil (PT)
- Institut de Biologie Moléculaire et Cellulaire (FR)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
Publication Details
- Journal
- Gastric Cancer
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1007/s10120-025-01620-y
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Universidade do Porto
- Fundação para a Ciência e a Tecnologia