Prostate Cancer in Southern Iran: The 16-year Mortality and Years of Life Lost from 2004 to 2019

Background: As of 2020, prostate cancer is the fifth most common cause of fatalities due to cancer in males and is also the second most common type of cancer overall.The purpose of this study was to look into the patterns of prostate cancer-related mortality and years of life lost (YLL) in the province of Fars.Materials and Methods: Data on all prostate cancer-related fatalities in the province of Fars were gathered for this cross-sectional investigation via the electronic population-based death registration system (EDRS).We calculated the crude mortality rate, age-standardized mortality rate (ASMR), years of life lost (YLL), and YLL rate.The JoinPoint Regression method was used to analyze the patterns over time.Results: During the 16-year study period from 2004 to 2019, there were 1,836 deaths from prostate cancer in Fars province.The crude and standardized mortality rates showed an increasing trend over this period.The total number of years of life lost (YLL) due to prostate cancer during these 16 years was 15,785.The highest number of YLL occurred in the age group of 70-79 years, while the lowest was observed in individuals under 30.According to join point regression analysis, the YLL rate due to premature mortality increased over the 16 years, with an annual percent change (APC) of 2.3% (95% CI 0.2 to 4.4, p=0.034).Conclusion: Prostate cancer-related death and YLL are on the rise, according to the study's findings.Therefore, it is necessary to improve diagnostic and therapeutic measures; more studies in this field are also recommended.