Measuring early vascular aging in youth: an expert consensus document from the Youth Vascular Consortium
Since the conceptualization of early vascular aging (EVA) in 2008, significant efforts have been made to develop and improve its assessment. Initially lead by the investigation of arterial stiffness through pulse wave velocity (PWV), several additional vascular aging biomarkers have gained prominence in recent years. Despite expanding literature addressing methodological concerns associated with these biomarkers in youth, a standardized approach for clinical evaluation of EVA remains elusive, leaving pertinent gaps in understanding the optimal methodology. This article, resulting from international consensus efforts from the Youth Vascular Consortium, aims to provide an updated overview of methods available to measure EVA in youth and to discuss challenges in translating these methods into clinical practice.
Authors
- Manish D. Sinha (ORCID: https://orcid.org/0000-0001-7593-1203)
- Ruan Kruger (ORCID: https://orcid.org/0000-0001-7680-2032)
- Daniel Bia (ORCID: https://orcid.org/0000-0001-7160-7166)
- Lee Stoner (ORCID: https://orcid.org/0000-0002-0682-2270)
- David S. Celermajer (ORCID: https://orcid.org/0000-0001-7640-0439)
- Keeron J. Stone (ORCID: https://orcid.org/0000-0001-6572-7874)
- Rosa María Bruno (ORCID: https://orcid.org/0000-0002-6107-3356)
- Henner Hanssen (ORCID: https://orcid.org/0000-0001-5501-4205)
- Rachel E. Climie (ORCID: https://orcid.org/0000-0002-7960-360X)
- Erzsébet Valéria Hidvégi (ORCID: https://orcid.org/0000-0003-4113-2395)
- Elaine M. Urbina (ORCID: https://orcid.org/0000-0002-5640-6777)
- Christopher J. A. Pugh (ORCID: https://orcid.org/0000-0002-5932-4793)
- Madeleine Johansson (ORCID: https://orcid.org/0000-0001-9057-9148)
- Yanina Zócalo (ORCID: https://orcid.org/0000-0002-6544-2518)
- Mieczysław Litwin (ORCID: https://orcid.org/0000-0002-5241-2483)
- Elisabetta Bianchini (ORCID: https://orcid.org/0000-0002-1827-8866)
- Vimarsha Kodithuwakku (ORCID: https://orcid.org/0000-0002-0657-3251)
- Giacomo Pucci
- Alejandro Díaz (ORCID: https://orcid.org/0000-0001-7536-3269)
- Karsten Königstein (ORCID: https://orcid.org/0000-0002-2994-8570)
- Jeanne Hersant (ORCID: https://orcid.org/0000-0002-7126-0534)
- Peter Nilsson
- José Geraldo Mill
Institutions
- University of North Carolina at Chapel Hill (US)
- Cincinnati Children's Hospital Medical Center (US)
- The University of Sydney (AU)
- University of Tasmania (AU)
- Inserm (FR)
- Universidad de la República de Uruguay (UY)
- King's College London (GB)
- University of Basel (CH)
- Lund University (SE)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Université Paris Cité (FR)
- University of Szeged (HU)
- University of Perugia (IT)
- North-West University (ZA)
- The Heart Research Institute (AU)
- Universidad Nacional del Centro de la Provincia de Buenos Aires (AR)
- British Heart Foundation (GB)
- Centro Científico Tecnológico - Tandil (AR)
- Istituto di Fisiologia Clinica (IT)
- Children's Memorial Health Institute (PL)
- Comisión Sectorial de Investigación Científica (UY)
- Paris Cardiovascular Research Center (FR)
- Skåne University Hospital (SE)
- Evelina London Children's Healthcare (GB)
- ASM Terni (Italy) (IT)
- National Research Council (IT)
- NIHR Research Delivery Network (GB)
- Université d'Angers (FR)
- Universidade Federal do Espírito Santo (BR)
- University of Cincinnati (US)
- University of Pecs (HU)
- Cardiff Metropolitan University (GB)
Publication Details
- Journal
- Journal of Hypertension
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1097/hjh.0000000000004039
- Citations
- 7
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 9.72