Obesity indicators mediate the association between the aggregate index of systemic inflammation (AISI) and type 2 diabetes mellitus (T2DM)
An increase in AISI is associated with an elevated probability of T2DM, with obesity indicators potentially mediating this relationship. Reducing AISI and managing obesity may help prevent T2DM. However, with the cross-sectional design of this study, causal relationships cannot be established. Future research should utilize longitudinal studies to confirm these findings.
Authors
- Lei Cao (ORCID: https://orcid.org/0000-0003-2378-8112)
- Peng Zhang (ORCID: https://orcid.org/0000-0002-4868-1306)
- Chun-Wei Wu (ORCID: https://orcid.org/0000-0002-6935-2499)
- Hailong Chen (ORCID: https://orcid.org/0000-0002-3456-7836)
- Jing Lü (ORCID: https://orcid.org/0000-0002-7725-1591)
- Ziying Su (ORCID: https://orcid.org/0009-0006-9686-5931)
- Ze He
Institutions
- Changchun University of Chinese Medicine (CN)
- Changchun University (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s12944-025-02589-4
- Citations
- 11
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 14.90