Spontaneous or photo-induced resolution of papular elastolytic giant cell granuloma? A case report with considerations on its etiopathogenesis and clinical approach

Papular elastolytic giant cell granuloma (PEGCG) is a rare subtype of elastolytic giant cell granuloma (EGCG), typically presenting as asymptomatic papules in non-photo-exposed areas and lacking annular or photo-distributed lesions. Histologically, it overlaps with other EGCG variants, showing features like elastolysis, elastophagocytosis, and multinucleated giant cell infiltrates. The etiopathogenesis remains unclear, particularly the role of ultraviolet (UV) radiation, and its clinical management is not well defined. We report a case of PEGCG that, after a one-year history, achieved complete clinical remission following two and a half months of sun exposure during the summer (heliotherapy). This case offers insights into its etiopathogenesis and clinical management, supported by a review of the existing literature.

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Publication Details

Journal
Dermatology Reports
Published
2025-05-14
DOI
https://doi.org/10.4081/dr.2025.10149
Primary Topic
Dermatological and Skeletal Disorders
Type
article
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article

Spontaneous or photo-induced resolution of papular elastolytic giant cell granuloma? A case report with considerations on its etiopathogenesis and clinical approach

Anna Rita Lombardi, Andrea Conti, Andrea Marani, Alessia Caligiure et al.
Dermatology Reports
Dermatological and Skeletal Disorders
article

Spontaneous or photo-induced resolution of papular elastolytic giant cell granuloma? A case report with considerations on its etiopathogenesis and clinical approach

Anna Rita Lombardi, Andrea Conti, Andrea Marani, Alessia Caligiure, Davide Bertolla
article en

Abstract

Papular elastolytic giant cell granuloma (PEGCG) is a rare subtype of elastolytic giant cell granuloma (EGCG), typically presenting as asymptomatic papules in non-photo-exposed areas and lacking annular or photo-distributed lesions. Histologically, it overlaps with other EGCG variants, showing features like elastolysis, elastophagocytosis, and multinucleated giant cell infiltrates. The etiopathogenesis remains unclear, particularly the role of ultraviolet (UV) radiation, and its clinical management is not well defined. We report a case of PEGCG that, after a one-year history, achieved complete clinical remission following two and a half months of sun exposure during the summer (heliotherapy). This case offers insights into its etiopathogenesis and clinical management, supported by a review of the existing literature.

Dermatology ReportsVol. 18(1)
University of Ferrara (IT), Ospedale Infermi di Rimini (IT), Union des Industries Ferroviaires Européennes (BE)
Good health and well-being
Openalex Percentile: Top 88%
Dermatological and Skeletal Disorders
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