The surface protein Gbp of Fusobacterium nucleatum inhibits osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2
This study demonstrates that Fn and its effector Gbp disrupt osteogenic differentiation by inactivating the Wnt/β-catenin pathway binding to ANXA2.
Authors
- Haiting Gao
- Qiang Feng (ORCID: https://orcid.org/0000-0002-4055-226X)
- Rui Dong (ORCID: https://orcid.org/0000-0001-9645-4768)
- Jun Zhang
- Xiaoping Gu
- Zhiqiang Wei (ORCID: https://orcid.org/0000-0003-1106-0087)
- Meihui Li (ORCID: https://orcid.org/0000-0002-2727-1391)
- Houbao Qi
Institutions
- Shandong University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s12967-025-06569-1
- Citations
- 5
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 7.33
Funders
- National Natural Science Foundation of China