Characteristics of the vaginal microbiota associated with recurrent spontaneous preterm birth: a prospective cohort study
L. iners dominance in the vaginal microbiota before 16 weeks of gestation is associated with an increased risk of recurrent sPTB, partly because of its propensity to transition to an unfavorable non-Lactobacillus-dominant state. This finding highlights the potential role of vaginal microbiota as an intervention target for reducing the risk of recurrent sPTB in early pregnancy.
Authors
- Xiaoxian Qu
- Ying Hao (ORCID: https://orcid.org/0009-0006-1802-2314)
- Jiaqi Dong (ORCID: https://orcid.org/0000-0002-2062-3040)
- Xiaohua Liu (ORCID: https://orcid.org/0000-0003-0905-1456)
- Xiang Li (ORCID: https://orcid.org/0000-0001-6145-7045)
- Luyao Wang (ORCID: https://orcid.org/0000-0002-9488-4040)
- Feng Zhang (ORCID: https://orcid.org/0000-0001-7468-0457)
- Xing Mao (ORCID: https://orcid.org/0000-0002-3942-9547)
- Xiang Jiang (ORCID: https://orcid.org/0000-0001-6827-7338)
- Yirong Bao
Institutions
- Jiangnan University (CN)
- Shanghai First Maternity and Infant Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s12967-025-06460-z
- Citations
- 6
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 8.13
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China