Population pharmacokinetics of vancomycin in non-extremely preterm neonates based on real-world studies: influence of daily fluid input and diuretics
A population pharmacokinetic model for vancomycin in neonatal intensive care unit neonates was developed. Daily fluid input and the use of diuretic agents were identified as new significant covariates influencing drug clearance. Based on these covariates, a dosing regimen was developed that provides clinicians with individualized dosing recommendations.
Authors
- Ying Chang (ORCID: https://orcid.org/0000-0002-5925-9821)
- Xin Zhai (ORCID: https://orcid.org/0009-0005-9727-6162)
- Kai Zhao (ORCID: https://orcid.org/0000-0003-0656-1901)
- Hui Chen (ORCID: https://orcid.org/0000-0001-6883-3752)
- Zhenguo Liu (ORCID: https://orcid.org/0000-0002-6694-988X)
- Fang Zhao (ORCID: https://orcid.org/0000-0002-8105-1189)
- Kwangho Ju
Institutions
- Northwest Women's and Children's Hospital (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1128/spectrum.02274-24
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shaanxi Provincial Science and Technology Department