Altered nasal and oral microbiomes define pediatric sickle cell disease

The oral and nasal cavities are susceptible to environmental exposures including pathogenic microbes. In individuals with systemic disorders, antibiotic exposure, changes to the immune system, or changes to organ function could influence the composition of the microbes at these sites and the overall health of individuals. Children with sickle cell disease (SCD) commonly experience respiratory infections, such as pneumonia or sinusitis, and may have increased susceptibility to infection because of disrupted microbiota at these body sites. We found that children with SCD (cwSCD) had more pathobiont bacteria in the nasal cavity and reduced bacterial diversity in the oral cavity compared to their healthy siblings. Defining when, why, and how these changes occur in cwSCD could help identify specific microbial signatures associated with susceptibility to infection or adverse outcomes, providing insights into personalized treatment strategies and preventive measures.

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Publication Details

Journal
mSphere
Published
2025-05-14
DOI
https://doi.org/10.1128/msphere.00137-25
Citations
2
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
1.61

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article

Altered nasal and oral microbiomes define pediatric sickle cell disease

Darryl B. Hood, Asunción Mejías, Michael Bailey, Stefanie Ebelt et al.
2 citations
mSphere
Gut microbiota and health
1.61
article

Altered nasal and oral microbiomes define pediatric sickle cell disease

Darryl B. Hood, Asunción Mejías, Michael Bailey, Stefanie Ebelt, Michelle Gillespie, Vivien Sheehan, Octavio Ramilo, Benjamin T. Kopp, Matthew Z. Anderson, Susan E. Creary, Audra L. Crouch, Beatrice M. Severance
article en
2 citations

Abstract

The oral and nasal cavities are susceptible to environmental exposures including pathogenic microbes. In individuals with systemic disorders, antibiotic exposure, changes to the immune system, or changes to organ function could influence the composition of the microbes at these sites and the overall health of individuals. Children with sickle cell disease (SCD) commonly experience respiratory infections, such as pneumonia or sinusitis, and may have increased susceptibility to infection because of disrupted microbiota at these body sites. We found that children with SCD (cwSCD) had more pathobiont bacteria in the nasal cavity and reduced bacterial diversity in the oral cavity compared to their healthy siblings. Defining when, why, and how these changes occur in cwSCD could help identify specific microbial signatures associated with susceptibility to infection or adverse outcomes, providing insights into personalized treatment strategies and preventive measures.

mSphereVol. 10(6)
St. Jude Children's Research Hospital (US), Nationwide Children's Hospital (US), University of Wisconsin–Madison (US), Emory University (US), Children's Healthcare of Atlanta (US), The Ohio State University (US)
Chan Zuckerberg Initiative, National Institutes of Health
Openalex Percentile: Top 17%
Gut microbiota and health
1.61
DOIOpen Access PDFOpenAlex
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