Immune control of metastatic cancer at the edge of the central nervous system

Leptomeningeal metastasis is a deadly consequence of cancer that creates an unusually inflamed environment around the brain and spinal cord. One of the inflammatory signalling molecules found in cerebrospinal fluid, interferon-γ, induces an antitumour immune response through an unexpected series of cell–cell interactions. The inflammatory molecule interferon-γ orchestrates precise interactions between six cell types in the cerebrospinal fluid.