Lactobacillus plantarum and Galacto-Oligosaccharides Synbiotic Relieve Irritable Bowel Syndrome by Reshaping Gut Microbiota and Attenuating Mast Cell Hyperactivation
In conclusion, the synbiotic composed of <i>L. plantarum</i> ZYC501 and GOS effectively alleviates IBS and associated colonic dysfunctions by modulating the gut microbiota, reducing mast cell hyperactivity, and enhancing colonic barrier integrity. These findings provide a theoretical basis for developing gut microbiota-targeted dietary interventions for the management of IBS and improvement in gut health.
Authors
- Jiawei Kang
- Yuze Wang (ORCID: https://orcid.org/0000-0003-3085-5299)
- Xudong Zheng (ORCID: https://orcid.org/0000-0003-2688-4855)
- Yuan Tian (ORCID: https://orcid.org/0000-0003-0192-3037)
- Yuanbin She (ORCID: https://orcid.org/0000-0002-1007-1852)
- Le Yi Shi (ORCID: https://orcid.org/0000-0002-8830-883X)
- Zhigang Liu (ORCID: https://orcid.org/0000-0002-6863-6561)
- Yu Zhao (ORCID: https://orcid.org/0000-0002-6680-2693)
- Yong Zhao (ORCID: https://orcid.org/0000-0003-0429-3296)
- Qi Yao (ORCID: https://orcid.org/0000-0002-4146-0914)
- Rui Guo (ORCID: https://orcid.org/0000-0002-1599-7806)
- Wenbo Zhang (ORCID: https://orcid.org/0000-0002-8875-5170)
- Jiarui Liang
Institutions
- Northwest A&F University (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2025-05-14
- DOI
- https://doi.org/10.3390/nu17101670
- Citations
- 7
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 12.68
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Shenzhen Fundamental Research Program
- Basic and Applied Basic Research Foundation of Guangdong Province