Plaque biofilm in periodontitis: past, present and future

Periodontitis is caused by an inappropriate activation of the host response to plaque biofilm. The accumulation of plaque biofilm leads to dysbiosis, that is, an imbalance in microbial community composition and function, which drives tissue destruction. Historical plaque hypotheses provide a foundational understanding of the role of plaque in the pathogenesis of periodontitis {AQ – edit OK?}. More contemporary theories emphasize how dysbiosis can trigger an exaggerated host response, leading to tissue destruction and periodontitis. As periodontitis is a biofilm-related disease, clinicians should be aware of the importance of regular mechanical disruption of plaque biofilm in managing periodontitis. CPD/Clinical Relevance: Practitioners should aware of the importance of regular professional mechanical plaque removal, which is integral to the overall management of periodontal disease.