Research Communication: Real‐World Effectiveness of Budesonide Orodispersible Tablets for Eosinophilic Oesophagitis: The Importance of Patience and Education
Budesonide orodispersible tablets (BOT) have been shown to be efficacious for eosinophilic oesophagitis (EoE) in clinical trials. This study evaluated the real-world effectiveness of BOT in a retrospective cohort of 94 patients across six tertiary centres. 61% of patients achieved histological remission and 39% clinicohistological remission following induction therapy. Adverse events were reported by 16% of patients and 17% were noted to have incorrect technique of administration. BOT was demonstrated to have lower rates of clinicohistological remission in real-world practice than reported in clinical trials, largely due to incorrect technique and cessation due to adverse events.
Authors
- Hamish Philpott (ORCID: https://orcid.org/0000-0002-1973-6355)
- Rebecca Burgell (ORCID: https://orcid.org/0000-0002-1344-8336)
- Catherine Yu (ORCID: https://orcid.org/0009-0001-0424-602X)
- Ayushi Chauhan (ORCID: https://orcid.org/0000-0002-2266-4903)
- Varan Perananthan (ORCID: https://orcid.org/0000-0002-4087-4998)
- Sarah Lucas (ORCID: https://orcid.org/0000-0002-4290-6631)
- Nikita Parkash (ORCID: https://orcid.org/0000-0003-2078-1556)
- Mayur Garg (ORCID: https://orcid.org/0000-0002-9149-3589)
- Diana J. Lewis (ORCID: https://orcid.org/0000-0002-1268-4492)
- Chamara Basnayake (ORCID: https://orcid.org/0000-0001-6103-769X)
- Katrina Tan
- Mani Suleiman (ORCID: https://orcid.org/0000-0002-5892-5095)
- Gloria Sepe
- Sarah Taylor
- Emily Barwick
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Northern Health (AU)
- La Trobe University (AU)
- St Vincent's Hospital Melbourne (AU)
- Eastern Health (AU)
- Women's and Children's Health Network (AU)
- Alfred Health (AU)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1111/apt.70197
- Citations
- 2
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- University of Melbourne