Rhodium-catalyzed isomerization of homoallylic alcohols with a tethered carbonyl group: pathway to 1,6-diketones
Herein, we report a rhodium-catalyzed isomerization of homoallylic alcohols with a tethered carbonyl group to synthesize structurally diverse unsymmetrical 1,6-diketones with atom, step, and redox economy. By introducing chiral ligands, good enantioselective isomerization products can be obtained. The utility of this reaction was also demonstrated with diverse transformations.
Authors
- Jie Wan
- Shuang Peng (ORCID: https://orcid.org/0000-0002-0163-9047)
- Bi‐Qin Wang
- Tong Su (ORCID: https://orcid.org/0009-0002-6136-584X)
- Xuan Yang
- Bin Chen (ORCID: https://orcid.org/0000-0002-9907-7002)
- Jiajie Li (ORCID: https://orcid.org/0000-0003-2499-5340)
- Peng Cao (ORCID: https://orcid.org/0000-0001-8199-0015)
- Ping Hu
- Hai‐Liang Ni (ORCID: https://orcid.org/0009-0000-1667-6214)
Institutions
- Sichuan Normal University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00473j
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China