Risk of Neck Hematoma Following Thyroidectomy in Patients Taking Direct Oral Anticoagulants: A Propensity Score Matching Analysis from Nine High-Volume European Centers (RAGNO Study)
<b>Background:</b> Postoperative neck hematoma is an infrequent but potentially fatal complication following thyroidectomy. The main aim of this study was to evaluate the impact of direct oral anticoagulants (DOACs) on the occurrence of this complication. <b>Methods:</b> Patients who underwent thyroidectomy between January 2020 and December 2022 in nine high-volume thyroid surgery centers in Europe were retrospectively evaluated. Based on taking direct oral anticoagulants, patients were divided into two groups: the DOAC Group and the Control Group. Propensity score matching 1:1 was performed between the two groups, which were then compared through a univariate analysis. <b>Results:</b> The total number of patients enrolled based on the inclusion/exclusion criteria was 8985. Following propensity score matching, the study population consisted of 316 patients: 158 in the DOAC Group and 158 in the Control Group. In the DOAC Group, the overall incidence of neck hematoma was 5.70% (4.43% for neck hematomas managed conservatively, and 1.27% for those that required surgical revision of hemostasis). No statistically significant difference was found between the two groups in terms of the incidence of this complication. Hospital readmission due to neck hematoma was not observed in any patient. No statistically significant difference was found between the two groups in terms of the timing of the onset of neck hematomas that required surgical revision of hemostasis. <b>Conclusions:</b> This study showed that direct oral anticoagulants, in the field of thyroid surgery, have no impact on the occurrence of postoperative neck hematoma. Therefore, based on our findings, it can be concluded that thyroidectomy can be safely performed in patients taking this class of drugs.
Authors
- Theodossis S. Papavramidis (ORCID: https://orcid.org/0000-0002-7097-9889)
- Angeliki Chorti (ORCID: https://orcid.org/0000-0003-1028-4476)
- Amelia Mattia (ORCID: https://orcid.org/0009-0006-4404-092X)
- Marco Raffaelli (ORCID: https://orcid.org/0000-0002-1259-2491)
- Valentine Luzuy‐Guarnero (ORCID: https://orcid.org/0000-0002-2276-0794)
- Pietro Princi (ORCID: https://orcid.org/0000-0003-0020-8496)
- Benoît Bédat (ORCID: https://orcid.org/0000-0002-3758-7867)
- Francesco Feroci (ORCID: https://orcid.org/0000-0002-6643-0981)
- Giulia Salvi (ORCID: https://orcid.org/0000-0003-0420-7351)
- Gian Luigi Canu (ORCID: https://orcid.org/0000-0003-3233-0269)
- Giulia Lanzolla (ORCID: https://orcid.org/0000-0001-9933-4040)
- Giulia Carnassale
- Serena Elisa Tempera (ORCID: https://orcid.org/0000-0003-4480-1806)
- Federico Cappellacci (ORCID: https://orcid.org/0000-0002-8101-8864)
- Emanuela Traini (ORCID: https://orcid.org/0000-0002-6387-6558)
- Tommaso Guagni (ORCID: https://orcid.org/0000-0003-2038-5748)
- Moysis Moysidis (ORCID: https://orcid.org/0000-0001-5383-0751)
- Francesco Pennestrì (ORCID: https://orcid.org/0000-0003-0865-700X)
- Francesco Boi (ORCID: https://orcid.org/0000-0002-9924-5192)
- Carlo Enrico Ambrosini (ORCID: https://orcid.org/0009-0005-9109-371X)
- Fabio Medas (ORCID: https://orcid.org/0000-0002-9546-0178)
- Leonardo Rossi (ORCID: https://orcid.org/0000-0003-4974-3860)
- Gabriele Materazzi (ORCID: https://orcid.org/0000-0002-3040-516X)
- Carmela De Crea (ORCID: https://orcid.org/0000-0002-7303-9657)
- Giacomo Di Filippo (ORCID: https://orcid.org/0000-0002-8466-6787)
- Pietro Giorgio Calò (ORCID: https://orcid.org/0000-0001-9637-1145)
- Pierpaolo Gallucci (ORCID: https://orcid.org/0000-0002-7000-538X)
- Marco Stefano Demarchi
- Giovanni Lazzari
- Martina Izzo
- Andrea De Palma (ORCID: https://orcid.org/0000-0001-6215-7298)
- Eleonora Morelli
- Ioannis Pliakos
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Verona (IT)
- University of Cagliari (IT)
- Aristotle University of Thessaloniki (GR)
- AHEPA University Hospital (GR)
- Agostino Gemelli University Polyclinic (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Kyanous Stavros Hospital (GR)
- Euromedica (GR)
- Ospedale San Carlo (IT)
- University Hospital of Geneva (CH)
- Ospedale Cristo Re (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
- Hospital of Prato (IT)
Publication Details
- Journal
- Journal of Clinical Medicine
- Published
- 2025-05-14
- DOI
- https://doi.org/10.3390/jcm14103435
- Citations
- 1
- Primary Topic
- Thyroid and Parathyroid Surgery
- Type
- article
- Field-Weighted Citation Impact
- 2.01