IL-9 Promotes Migratory Dissemination of Malignant T Cells by Activating the HIF-1α–Cofilin-1 Axis in Cutaneous T-cell Lymphoma
Our results uncover a CTCL-intrinsic IL-9-HIF-1α-CFL-1 axis as a critical promoter of malignant T-cell migration. They further identify HIF-1α and CFL-1 as promising therapeutic targets to mitigate IL-9-induced CTCL dissemination.
Authors
- Ditipriya Mukherjee (ORCID: https://orcid.org/0000-0002-7259-5520)
- Hasmukh Jain (ORCID: https://orcid.org/0000-0002-9947-7065)
- Diksha Attrish (ORCID: https://orcid.org/0000-0001-5622-5899)
- Steven R. Barthel (ORCID: https://orcid.org/0000-0003-2107-4570)
- Rahul Purwar (ORCID: https://orcid.org/0000-0003-3319-0309)
- Sushant Kumar (ORCID: https://orcid.org/0000-0002-7983-6761)
- Moumita Basu (ORCID: https://orcid.org/0000-0001-6691-5279)
- Soumitra Marathe (ORCID: https://orcid.org/0000-0002-7712-6061)
- Bhavuk Dhamija (ORCID: https://orcid.org/0000-0002-2015-2234)
- Vinanti Sawant (ORCID: https://orcid.org/0000-0001-6947-4026)
- Siddhi Wad (ORCID: https://orcid.org/0000-0002-2398-9515)
- Neha Sharma (ORCID: https://orcid.org/0000-0002-5540-0509)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Indian Institute of Technology Bombay (IN)
- Tata Memorial Hospital (IN)
Publication Details
- Journal
- Molecular Cancer Research
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1158/1541-7786.mcr-24-1020
- Primary Topic
- Cutaneous lymphoproliferative disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Biotechnology, Ministry of Science and Technology, India
- Indian Council of Medical Research
- Indian Institute of Technology Bombay