Impact of Mechanical Ventilation and Anesthesia on PET Tracer Kinetics for Combined PET/fMRI Studies in Rats
These findings underscore the profound impact of mechanical ventilation and anesthesia selection on PET tracer kinetics in hybrid PET/fMRI studies. The study highlights that those protocols established for fMRI are not directly transferable to PET imaging in small animals, emphasizing the necessity for a careful investigation of the influence of anesthesia and ventilation techniques on tracer kinetics.
Authors
- Andreas Maurer (ORCID: https://orcid.org/0000-0003-2412-5361)
- Laura Kuebler (ORCID: https://orcid.org/0000-0002-6986-403X)
- Yan Ma (ORCID: https://orcid.org/0000-0003-1510-3232)
- Kristina Herfert (ORCID: https://orcid.org/0000-0003-0231-7717)
- Sabrina Haas (ORCID: https://orcid.org/0009-0006-9003-8708)
Institutions
- Siemens (Germany) (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Max Planck Institute for Biological Cybernetics (DE)
- Hertie Institute for Clinical Brain Research (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1007/s11307-025-02006-3
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Carl-Zeiss-Stiftung
- Deutsche Forschungsgemeinschaft
- China Scholarship Council
- Universitätsklinikum Tübingen