SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer

Pol II stalling induced by SMARCA4 loss leads to R-loop accumulation that sequesters BRCA1 to transcription complexes, underlying the sensitivity of SMARCA4-deficient ovarian cancers to inhibitors targeting PARPs and Pol II elongation.

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Publication Details

Journal
Cancer Research
Published
2025-05-14
DOI
https://doi.org/10.1158/0008-5472.can-24-3990
Citations
2
Primary Topic
Chromatin Remodeling and Cancer
Type
article
Field-Weighted Citation Impact
1.61
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article

SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer

Zheng Fu, Virginie Pilon, W. Glenn McCluggage, Yibo Xue et al.
2 citations
Cancer Research
Chromatin Remodeling and Cancer
1.61
article

SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer

Zheng Fu, Virginie Pilon, W. Glenn McCluggage, Yibo Xue, Anie Monast, Alexander J.R. Bishop, Giulio Aceto, Walter H. Gotlieb, William D. Foulkes, Azadeh Arabzadeh, Xianbing Zhu, Douglas A. Levine, Alica Valachová, Brian Raught, Kitty Pavlakis, Sidong Huang, Amber Yasmeen, Jonathan St‐Germain, Leora Witkowski, Geneviève Morin, Jingjie Guo, Nicklas Bassani, Jutta Steinberger, David G. Huntsman, Yemin Wang, Morag Park, Selim Mısırlıoğlu, Yuxuan Qi, Lili Fu, Kexin Liu, Elise Graulich, Racim Sansal
article en
2 citations

Abstract

Pol II stalling induced by SMARCA4 loss leads to R-loop accumulation that sequesters BRCA1 to transcription complexes, underlying the sensitivity of SMARCA4-deficient ovarian cancers to inhibitors targeting PARPs and Pol II elongation.

Cancer ResearchVol. 85(16)
New York City Health and Hospitals Corporation (US), Merck & Co., Inc., Rahway, NJ, USA (United States) (US), Belfast Health and Social Care Trust (GB), Nationwide Children's Hospital (US), University Health Network (CA), Vancouver Coastal Health (CA), University of British Columbia (CA), The University of Texas at San Antonio Health Science Center (US), University of Toronto (CA), McGill University Health Centre (CA), Jewish General Hospital (CA), Princess Margaret Cancer Centre (CA), NYU Langone Health (US), Vysoká škola manažmentu, City University of Seattle (SK), Children's Hospital of San Antonio (US), Merck Institute for Science Education (US), McGill Genome Centre (CA), IASO General Hospital (GR), Molecular Oncology (United States) (US), Trencianska Univerzita Alexandra Dubceka V Trencine (SK), Iaso Children’s Hospital (GR), McGill University (CA), The University of Texas Health Science Center at Houston (US)
Good health and well-being
Openalex Percentile: Top 17%
Chromatin Remodeling and Cancer
1.61
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