Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Tumor suppressor genes with segmental duplications have an increased risk for somatic alterations, including deletions and structural variations, in human cancers, identifying them as a genetic Achilles' heel in tumor suppression.

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Publication Details

Journal
Cancer Research
Published
2025-05-14
DOI
https://doi.org/10.1158/0008-5472.can-24-2225
Citations
1
Primary Topic
Genomic variations and chromosomal abnormalities
Type
article
Field-Weighted Citation Impact
1.82

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article

Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

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Cancer Research
Genomic variations and chromosomal abnormalities
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article

Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Likai Tan, Yushan Wang, Ziheng Huang, Yingzhi Liu, Tony Gin, Sunny Hei Wong, Matthew T.V. Chan, Ka‐Fai To, Alfred S.L. Cheng, Dan Huang, William Ka Kei Wu, Xiaodong Liu, Huarong Chen, Wei Kang, Lin Zhang, Xinyi Zhang, Jun Qing Yu, Maggie Haitian Wang, Le Yu, Xiansong Wang, Ho Ko
article en
1 citations

Abstract

Tumor suppressor genes with segmental duplications have an increased risk for somatic alterations, including deletions and structural variations, in human cancers, identifying them as a genetic Achilles' heel in tumor suppression.

Cancer ResearchVol. 85(15)
Sun Yat-sen University (CN), Nanyang Technological University (SG), Chinese University of Hong Kong (HK), Southern Medical University (CN)
Research Grants Council, University Grants Committee, Health and Medical Research Fund
Openalex Percentile: Top 16%
Genomic variations and chromosomal abnormalities
1.82
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