Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations
Tumor suppressor genes with segmental duplications have an increased risk for somatic alterations, including deletions and structural variations, in human cancers, identifying them as a genetic Achilles' heel in tumor suppression.
Authors
- Likai Tan (ORCID: https://orcid.org/0000-0001-7555-9472)
- Yushan Wang (ORCID: https://orcid.org/0000-0003-2118-9554)
- Ziheng Huang (ORCID: https://orcid.org/0000-0002-6643-5707)
- Yingzhi Liu (ORCID: https://orcid.org/0000-0001-8717-3841)
- Tony Gin (ORCID: https://orcid.org/0000-0001-7283-6761)
- Sunny Hei Wong (ORCID: https://orcid.org/0000-0002-3354-9310)
- Matthew T.V. Chan (ORCID: https://orcid.org/0000-0002-3574-7855)
- Ka‐Fai To (ORCID: https://orcid.org/0000-0003-4919-3707)
- Alfred S.L. Cheng (ORCID: https://orcid.org/0000-0003-2345-6951)
- Dan Huang (ORCID: https://orcid.org/0000-0003-3022-5772)
- William Ka Kei Wu (ORCID: https://orcid.org/0000-0002-5662-5240)
- Xiaodong Liu (ORCID: https://orcid.org/0000-0002-5915-4499)
- Huarong Chen (ORCID: https://orcid.org/0000-0003-2192-1864)
- Wei Kang (ORCID: https://orcid.org/0000-0002-4651-677X)
- Lin Zhang
- Xinyi Zhang (ORCID: https://orcid.org/0000-0002-7144-5037)
- Jun Qing Yu (ORCID: https://orcid.org/0000-0001-5008-2153)
- Maggie Haitian Wang (ORCID: https://orcid.org/0000-0003-1223-4595)
- Le Yu (ORCID: https://orcid.org/0000-0002-9773-1162)
- Xiansong Wang (ORCID: https://orcid.org/0000-0001-7308-0978)
- Ho Ko (ORCID: https://orcid.org/0000-0002-0254-3274)
Institutions
- Sun Yat-sen University (CN)
- Nanyang Technological University (SG)
- Chinese University of Hong Kong (HK)
- Southern Medical University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1158/0008-5472.can-24-2225
- Citations
- 1
- Primary Topic
- Genomic variations and chromosomal abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Research Grants Council, University Grants Committee
- Health and Medical Research Fund