Long-Term Oncologic Outcome of Breast-Conserving Treatment in Patients With Breast Cancer With <i>BRCA </i>Variants
The findings from this cohort study of patients with BRCA1 or BRCA2 pathogenic variants suggested that there were no significant differences in oncologic outcomes between patients who underwent BCT and those who underwent mastectomy. Therefore, breast conservation with close surveillance can be considered a viable treatment option for BRCA1 or BRCA2 pathogenic variant carriers. Further studies incorporating prospectively collected data are warranted to validate our findings.
Authors
- Sae Byul Lee (ORCID: https://orcid.org/0000-0002-3370-6937)
- Seon-Hi Shin (ORCID: https://orcid.org/0000-0003-2682-0560)
- Sung Gwe Ahn (ORCID: https://orcid.org/0000-0002-8778-9686)
- Chihwan Cha (ORCID: https://orcid.org/0000-0003-4522-9565)
- Jai Min Ryu (ORCID: https://orcid.org/0000-0001-5405-7385)
- Eunju Shin
- Min Sung Chung (ORCID: https://orcid.org/0000-0001-5086-3718)
- Sun Young Min (ORCID: https://orcid.org/0000-0003-2912-1167)
- Byeongju Kang (ORCID: https://orcid.org/0000-0002-3589-5559)
- Young-Joon Kang (ORCID: https://orcid.org/0000-0002-6546-0513)
- Sanghwa Kim (ORCID: https://orcid.org/0000-0003-4387-1976)
- Eun Young Kim (ORCID: https://orcid.org/0000-0002-5816-6519)
- M. H. Lee (ORCID: https://orcid.org/0000-0002-4082-1677)
- Hong Kyu Kim (ORCID: https://orcid.org/0000-0003-4425-972X)
- Hyung Seok Park (ORCID: https://orcid.org/0000-0003-3141-4858)
- Jisoo Shin
- Janghee Lee (ORCID: https://orcid.org/0000-0002-1311-2488)
- Junwon Go
Institutions
- Ulsan College (KR)
- Ewha Womans University (KR)
- Yonsei University (KR)
- Kyungpook National University Hospital (KR)
- Asan Medical Center (KR)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- University of Ulsan (KR)
- The Catholic University of Korea Incheon St. Mary's Hospital (KR)
- Kangbuk Samsung Hospital (KR)
- Kyung Hee University Dental Hospital (KR)
- Gangnam Severance Hospital (KR)
- Hanyang University Medical Center (KR)
- Biostatistical Consulting (United States) (US)
- Hallym University Sacred Heart Hospital (KR)
- Hanyang University (KR)
- Keimyung University (KR)
- New York University (US)
- Sungkyunkwan University (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.9840
- Citations
- 3
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.45