Cobalt-Catalyzed Regio- and Stereoselective C(sp<sup>2</sup>)–H Alkylation of Enamides with 4-Alkyl-1,4-dihydropyridines
We report herein an efficient cobalt-catalyzed regioselective and stereoselective alkenyl C(sp<sup>2</sup>)-H alkylation of structurally diverse enamides with 4-alkyl-1,4-dihydropyridines (DHPs) as the alkyl radical precursors. This DHPs-based approach features a broad substrate scope and excellent compatibility with diverse functionalities, giving rise to geometrically defined β-alkylated enamides with an exclusive <i>E</i> configuration. Preliminary mechanistic studies suggest a radical-involved pathway.
Authors
- Mingyu Chu
- Mengyang Wang (ORCID: https://orcid.org/0000-0003-2406-9996)
- Teck‐Peng Loh (ORCID: https://orcid.org/0000-0002-2936-337X)
- M. N. SHENG
- Xueqing Wen
- Mingzhu Lu (ORCID: https://orcid.org/0000-0002-6333-0803)
- Min‐Zhi Deng (ORCID: https://orcid.org/0009-0000-1960-5294)
Institutions
- Nanyang Technological University (SG)
- Henan University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1021/acs.orglett.5c01577
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province